Monday, 22 August 2016

Are you offering a Saliva based Hormone Diagnostic Service within UK/Europe? Then you will need to source the most accurate CE marked Kits available

We have been supplying a great many Functional Testing Laboratories within UK/Europe for many years with CE marked Diagnostic Saliva based Assays

Chosen for our accuracy, reliability, reproducibility, minimally invasive use and of course competitive pricing

For UK/Europe we offer CE Marked Assays for: Cortisol, Cotinine, DHEA, DHEA-S, Estradiol, Estriol, Progesterone, Testosterone, Collection Devices and Training (Held at Salimetrics Cambridge Laboratory or On-Site, ask for pricing)

Our Saliva based Cortisol Assay offers 76 singlet tests,  a sensitivity of <0.007 ug/dL, Serum/Saliva Correlation of 0.91 with an incubation time of 1.5hrs. 

Cortisol Assay Kit (CE) (76 Singlet) Cost: £189 (Euro 264.60)

So thats a singlet cost of £2.50 (Euro 3.50) per test

To add us to your portfolio e mail:

+44 (0)1638 782619

Wednesday, 10 August 2016

A probabilistic model for Cushing’s syndrome screening in at-risk populations: a prospective multicenter study

A probabilistic model for Cushing’s syndrome screening in at-risk populations: a prospective multicenter study

Antonio León-Justel, Ainara Madrazo-Atutxa, Ana I. Alvarez-Rios,
Rocio Infantes-Fontán, Juan A. Garcia-Arnés, Juan A. Lillo-Muñoz, Anna Aulinas, Eulàlia Urgell-Rull, Mauro Boronat, Ana Sánchez-de-Abajo,
Carmen Fajardo-Montañana, Mario Ortuño-Alonso, Isabel Salinas-Vert,
Maria L. Granada, David A. Cano, Alfonso Leal-Cerro, for the Spanish CRISALIDA study group 

Medicine Department, Huelva University Hospital, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla (A.L- J.); Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla. (A.M.A., D.A.C., A.L.-C.); Department of Clinical Biochemistry, Virgen del Rocío University Hospital (IBiS/CSIC/SAS/University of Seville) (A.I.A.R.); Servicio de Bioquímica, Sección Hormonas especiales, Hospital Universitario Virgen del Rocio, Sevilla (R.I.F.); Department of Clinical Endocrinology and Nutrition, Carlos Haya Hospital, Málaga (J.A.G.-A.); Hospital Regional Universitario de Málaga (J.A.L.-M.); Pituitary Disease Research Group/Dept Endocrinology/Medicine, Hospital Sant Pau, Universitat Autónoma de Barcelona and CIBERER U747, ISCIII (A.A.); Clinical Biochemistry Department, Hospital de Sant Pau, Barcelona (E.U.R); Sección de Endocrinología y Nutrición, Hospital Universitario Insular, Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de Las Palmas de Gran Canaria (M.B.); Servicio de Bioquímica Clínica, Hospital Universitario Insular de Gran Canaria (A.S.- D.-A); H Universitario de La Ribera, Alzira (C.F.-M., M.O.-A.); Servicio Endocrinología y Nutrición, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona (I.S.-V.); Servicio de Bioquímica, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona (M.L.G.) 

Context: Cushing’s syndrome (CS) is challenging to diagnose. Increased prevalence of CS in specific patient populations has been reported but routine screening for CS remains questionable. To decrease the diagnostic delay and improve disease outcomes, new simple screening methods for CS in at-risk populations are needed.
Objective: To develop and validate a simple scoring system to predict CS based on clinical signs and an easy-to-use biochemical test.
Design: Observational, prospective, multicenter.
Setting: Referral Hospital.
Patients: A cohort of 353 patients attending Endocrinology Units for outpatient visits.
Interventions: All patients were evaluated with late-night salivary cortisol (LNSC) and low-dose dexamethasone suppression test (DST) for CS.
Main Outcome Measures: Diagnosis or exclusion of CS. 

Results: 26 cases of CS were diagnosed in the cohort. A risk scoring system was developed by logistic regression analysis and cutoff values were derived form a receiver operating characteristic curve (ROC). This risk score included clinical signs and symptoms (muscular atrophy, osteoporosis, and dorsocervical fat pad) and LNSC levels. The estimated area under the ROC curve was 0.93 with a sensitivity of 96.2% and specificity of 82.9%.
Conclusions: We developed a risk score to predict CS in at-risk population. This score may help to identify at-risk patients in non-endocrinological settings such as primary care but external valida- tion is warranted. 

Link to open access paper

Link to Salimetrics Diagnostic Salivary Cortisol Assay Specification

Tuesday, 19 July 2016

Mid Year Research Summary, Professor Douglas Granger Founder and Chief Scientific & Strategy Advisor to Salimetrics

Link to UCI Institute for Interdisciplinary Salivary Bioscience Research

An update from our founder - Prof. Doug Granger's
publications coming soon in 2016!

Liu, Y., Granger, D. A., Klein, L. C., Almeida, D. M., & Zarit, S. H. (minor revisions). Diurnal salivary alpha-amylase dynamics among dementia family caregivers: daily stress and adult day services use. Health Psychology

Kornienko, O., Schaefer, D. R., & Granger, D. A. (accepted minor revisions). Social networks, stress hormones, and Adolescent Development. In Hopcroft, R. (Ed), Oxford Handbook of Evolution, Biology, and Society. Oxford University Press.

Hutchinson, C., Laporta, A. J., Moloff, A., Lea, M., Ketchum, R., Franciose, R., Alson, R., Czekajlo, M., Lavell, K., Markham, S. Field, R. D., Hoang, T. N., & Granger, D.A. (minor revisions). Salivary cortisol and alpha-amylase response to hyper-realistic emergency trauma simulation in military medical students. Journal of Surgical Education.

Buckingham-Howes, S., Mazza, D, Wang, Y., Granger, D. A., & Black, M. (in press). Prenatal drug exposure and adolescent cortisol reactivity: association with behavioral concerns. Journal of Developmental & Behavioral Pediatrics.

Exum, N. G., Pisanic, N., Granger, D. A., Schwab, K. J., Detrick, B., Kosek, M., Egorov, A. I., Griffin, S. M., & Heaney, C. D. (in press). Use and application of biomarkers to estimate waterborne infections. Current Environmental Health Reports.

Berry, D., Blair, C., Willoughby, M., Raver, C., Granger, D. A., Mills-Koonce, R., & the Family Life Project key Investigators (in press). Maternal sensitivity and adrenocortical functioning across infancy and toddlerhood: Physiological adaptation to context? Development and Psychopathology PMID 27065311

Lucas-Thompson, R., Lunkenheimer, E., & Granger, D. A. (in press). Adolescents conflict appraisals moderate the link between marital conflict and physiological stress reacitivity. Journal of Research on Adolescence.

Stroud, C. B., Chen, F. R., Doane, L. D. & Granger, D. A. (in press). Individual Differences in Early Adolescents’ Latent Trait Cortisol (LTC): Relation to early adversity. Developmental Psychobiology PMID 26990202

Finegood, E. D., Blair, C., Granger, D. A., Hibel, L. C., Mills-Koonce, R., & The Family Life Project Investigators. (in press). Psychobiological influences on maternal sensitivity in the context of adversity. Developmental Psychology

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Tuesday, 12 July 2016

Better Together - Salivary Testosterone & Cortisol

Renewed interest by the research community has focused on the salivary testosterone/cortisol (T/C) ratio and its supporting biological mechanisms. Here we explore the scientific literature and provide a summary of our findings

Research suggests that testosterone and cortisol work together as part of a biological system influencing very basic and primary reactions to threats by balancing the hypothalamus-pituitary-adrenal (HPA) axis and the hypothalamus-pituitary-gonadal (HPG) axis responses (9). In response to a stressor, the human body increases the production of cortisol and decreases production of testosterone (12). In sports and exercise studies, salivary bioscience researchers have already concluded that the balancing of the T/C ratio not only supports a healthier lifestyle, but it can also act as a hormonal biomarker that targets overtraining and susceptibility to certain diseases and disorders (5,10).

General findings in the context of exercise and sports performance show the value of the salivary T/C ratio when observing training intensity levels and for determining potential overtraining and recovery (3, 7). This is often seen when there is evidence of a low or decreased T/C ratio (i.e., cortisol rises and testosterone decreases (2). In athletes, the T/C ratio has also been associated with skeletal muscle atrophy, as it may be reflective of the anabolism/catabolism balance of skeletal muscle as well (11).

However, the salivary T/C story doesn’t end with sports and performance. Additional research is beginning to encompass a much broader impact of the T/C ratio by expanding into the field of social biology. Findings related to social aggression and the T/C ratio have revealed a significant positive relationship between testosterone and aggression in subjects with high cortisol levels, but not in subjects with average to low cortisol levels (8). Now, research is beginning to elucidate the T/C ratio as a consistent hormonal marker for social aggression and criminal or aggressive tendencies (8,9).

While research continues to define the significant health implications of monitoring the T/C ratio by further understanding its biobehavioral influences, the team at Salimetrics stands ready to support you with convenient sample collection methods, salivary analysis and accurate results, so that you can unlock the potential of the T/C ratio in your research

1. Guilhem, G. et al (2015). Salivary Hormones Response to Preparation and Pre-competitive Training of World-class Level Athletes. Front Physiol, PMID, 26635619.
2. Lippi, G. et al (2016). Analytical Evaluation of Free Testosterone and Cortisol Immunoassays in Saliva as a Reliable Alternative to Serum in Sports Medicine. J Clin Lab Anal, PMID, 26990800.
3. Kreher, J.B. et al (2012). Overtraining Syndrome. Sports Health, 4(2), 128–138.
4. Hug, M. et al (2003). Training modalities: over-reaching and over-training in athletes, including a study of the role of hormones. Best Pract Res Clin Endocrinol Metab, 17(2), 191-209.
5. Filaire, E. et al (2001). Preliminary results on mood state, salivary testosterone:cortisol ratio and team performance in a professional soccer team. Eur J Appl Physiol, 86(2), 179-84.
6. Ghiciuc, C.M. et al (2015). Imbalance in the diurnal salivary testosterone/cortisol ratio in men with severe obstructive sleep apnea: an observational study. Braz J Otorhinolaryngol, S1808-8694(15), 00241-4.
7. Glenn, A.L. et al (2012). Increased testosterone to cortisol ratio in psychopathy. J Abnorm Psychol, 120(2), 389-399.
8. Denson, T.F. et al (2013). Endogenous testosterone and cortisol jointly influence reactive aggression in women. Psychoneuroendocrinology, 38(3), 416-24.
9. Terburg, D. et al (2009). The testosterone-cortisol ratio: A hormonalmarker for proneness to social aggression. Int J Law Psychiatry, 32(4), 216-23

Talk to us about our World Leading Salivary Cortisol and Salivary Testosterone Assays

+44 (0) 1638 782619